SHP1 antibody (Tyr536)

Catalog No. ABIN5957429

This Rabbit Polyclonal antibody specifically detects SHP1 in WB, ELISA and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SHP1 antibody (Tyr536) (ABIN5957429)

Target: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SHP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SHP1 Antibody

Binding Specificity: Tyr536

Specificity: 70Z-SHP,EC 3.1.3.48,HCP,HCPH,Hematopoietic cell phosphatase,Hematopoietic cell protein tyrosine phosphatase,Hematopoietic cell protein-tyrosine phosphatase,HPTP1C,Protein tyrosine phosphatase 1C,Protein tyrosine phosphatase non receptor type 6,Protein tyrosine phosphatase SHP1,Protein-tyrosine phosphatase 1C,protein-tyrosine phosphatase SHP 1,Protein-tyrosine phosphatase SHP-1,PTN6,PTP 1C,PTP-1C,PTP1C,Ptpn6,SH PTP 1,SH PTP1,SH-PTP1,SHP 1,SHP 1L,SHP1,SHP1L,tyrosine protein phosphatase non receptor type 6,Tyrosine-protein phosphatase non-receptor type 6

Purification: Affinity purification

Immunogen: Synthesized peptide derived from human SH-PTP1 around the non-phosphorylation site of Y536.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide,0.5 % BSA and 50 % glycerol  pH 7.4.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SHP1

Target: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Alternative Name: SH-PTP1

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

Molecular Weight: 68kDa

Gene ID: 5777

UniProt: P29350

Pathways: JAK-STAT Signaling, TCR Signaling, TLR Signaling, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling