MID1 antibody

Catalog No. ABIN5958299

Product Details anti-MID1 Antibody

Target: MID1 (Midline 1 (MID1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MID1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: BBBG 1,BBBG1,E3 ubiquitin-protein ligase Midline-1,Finger on X and Y mouse homolog of,FXY,GBBB 1,GBBB1,MID 1,Mid1,Midin,Midline 1 (Opitz/BBB syndrome),Midline 1,Midline 1 ring finger,Midline 1 RING finger protein,Midline-1,Midline1,OGS 1,OGS1,OS,OSX,Putative transcription factor XPRF,RING finger protein 59,RING finger protein Midline-1,RNF 59,RNF59,TRI18,TRI18,TRIM 18,TRIM18,Tripartite motif containing protein 18,Tripartite motif protein TRIM18,Tripartite motif-containing protein 18,XPRF,zinc finger on X and Y,mouse,homolog of,Zinc finger X and Y,ZNFXY

Purification: Affinity purification

Immunogen: Synthesized peptide derived from the N-terminal region of human Midline-1

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MID1

Target: MID1 (Midline 1 (MID1))

Alternative Name: Midline-1 (MID1 Products)

Synonyms: BBBG1 antibody, FXY antibody, GBBB1 antibody, MIDIN antibody, OGS1 antibody, OS antibody, OSX antibody, RNF59 antibody, TRIM18 antibody, XPRF antibody, ZNFXY antibody, 61B3-R antibody, DXHXS1141 antibody, Fxy antibody, Trim18 antibody, Midline1 antibody, bbbg1 antibody, fxy antibody, gbbb1 antibody, midin antibody, ogs1 antibody, osx antibody, rnf59 antibody, trim18 antibody, xprf antibody, znfxy antibody, midline 1 antibody, midline 1 L homeolog antibody, MID1 antibody, Mid1 antibody, mid1 antibody, mid1.L antibody

Background: The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Alternative promoter use, alternative splicing and alternative polyadenylation result in multiple transcript variants that have different tissue specificities.

Molecular Weight: 75kDa

Gene ID: 4281

UniProt: O15344