Clusterin antibody

Catalog No. ABIN5962710

Product Details anti-Clusterin Antibody

Target: Clusterin (CLU)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Clusterin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: 40,AAG 4,AAG4,Aging associated protein 4,Aging-associated gene 4 protein,AI893575,APO J,Apo-J,APOJ,ApoJalpha,ApoJbeta,Apolipoprotein J,ApolipoproteinJ,CLI,CLU,CLU1,CLU2,CLUS,Clusterin alpha chain,Clusterin,Clusterin beta chain,Complement associated protein SP 40 40,Complement associated protein SP 40,Complement associated protein SP40,Complement cytolysis inhibitor a chain,Complement cytolysis inhibitor,Complement cytolysis inhibitor b chain,Complement lysis inhibitor,Complement-associated protein SP-40,D14Ucla3,Dimeric acid glycoprotein,Glycoprotein 80,Glycoprotein III,GP80,Ku70-binding protein 1,KUB 1,KUB1,MGC24903,NA1/NA2,RATTRPM2B,SGP 2,SGP2,SP 40,SP40,Sugp-2,Sulfated glycoprotein 2,Testosterone repressed prostate message 2,Testosterone-repressed prostate message 2,TRPM 2,TRPM-2,TRPM2,TRPM2B,Trpmb

Purification: Affinity purification

Immunogen: Synthesized peptide derived from human CLUS Polyclonal

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000, ELISA 1:10000-20000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide,0.5 % BSA and 50 % glycerol  pH 7.4.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Clusterin

Target: Clusterin (CLU)

Alternative Name: CLUS (CLU Products)

Synonyms: LOC100136120 antibody, clu antibody, MGC53055 antibody, zgc:73352 antibody, xclu antibody, MGC89163 antibody, CLU antibody, APO-J antibody, APOJ antibody, CLI antibody, CLU1 antibody, CLU2 antibody, KUB1 antibody, NA1/NA2 antibody, SGP-2 antibody, SGP2 antibody, SP-40 antibody, TRPM-2 antibody, TRPM2 antibody, DAG antibody, RATTRPM2B antibody, SP40 antibody, TRPM2B antibody, Trpm2 antibody, Trpmb antibody, AI893575 antibody, ApoJ antibody, Cli antibody, D14Ucla3 antibody, Sgp-2 antibody, Sgp2 antibody, Sugp-2 antibody, GP80 antibody, gpIII antibody, 40 antibody, clusterin-1 antibody, clusterin L homeolog antibody, clusterin antibody, Clusterin antibody, LOC100136120 antibody, clu.L antibody, clu antibody, CLU antibody, clus antibody, Clu antibody, LOC101113728 antibody

Background: Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

Gene ID: 1191

UniProt: P10909

Pathways: Apoptosis, Negative Regulation of intrinsic apoptotic Signaling