AKR1C4 antibody

Catalog No. ABIN5962857

Product Details anti-AKR1C4 Antibody

Target: AKR1C4 (Aldo-keto Reductase Family 1 Member C4 (AKR1C4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AKR1C4 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human AKR1C4

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for AKR1C4

Target: AKR1C4 (Aldo-keto Reductase Family 1 Member C4 (AKR1C4))

Alternative Name: AKR1C4 (AKR1C4 Products)

Synonyms: 3-alpha-HSD antibody, C11 antibody, CDR antibody, CHDR antibody, DD-4 antibody, DD4 antibody, HAKRA antibody, aldo-keto reductase family 1 member C4 antibody, AKR1C4 antibody

Background:

Synonyms: 3 alpha HSD1,3-alpha-HSD1,3-alpha-hydroxysteroid dehydrogenase type I,AK1C4,AKR1C4,Aldo keto reductase family 1 member C4,Aldo-keto reductase family 1 member C4,CDR,Chlordecone reductase,DD-4,DD4,Dihydrodiol dehydrogenase 4,HAKRA

Background: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Molecular Weight:

Observed_MW: 37kDa

Calculated_MW: 37kDa

Gene ID: 1109

UniProt: P17516

Pathways: Steroid Hormone Biosynthesis