Asialoglycoprotein Receptor 1 antibody

Catalog No. ABIN5962979

Product Details anti-Asialoglycoprotein Receptor 1 Antibody

Target: Asialoglycoprotein Receptor 1 (ASGR1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Asialoglycoprotein Receptor 1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human ASGR1

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Asialoglycoprotein Receptor 1

Target: Asialoglycoprotein Receptor 1 (ASGR1)

Alternative Name: ASGR1 (ASGR1 Products)

Synonyms: ASGR1 antibody, ASGPR antibody, ASGPR1 antibody, CLEC4H1 antibody, HL-1 antibody, Asgr antibody, Asgr-1 antibody, ASGR antibody, RATRHL1 antibody, RHL1 antibody, asialoglycoprotein receptor 1 antibody, LOC721786 antibody, ASGR1 antibody, LOC489461 antibody, Asgr1 antibody, LOC101116157 antibody

Background:

Synonyms: ASGP-R 1,ASGPR 1,ASGPR,ASGPR1,Asgr1,ASGR1,Asialoglycoprotein receptor 1,C type lectin domain family 4 member H1,C-type lectin domain family 4 member H1,CLEC4H1,Hepatic lectin H1,HL-1

Background: This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Molecular Weight:

Observed_MW: 45kDa

Calculated_MW: 29kDa/33kDa

Gene ID: 432

UniProt: P07306

Pathways: Thyroid Hormone Synthesis