Desmocollin 2 antibody

Catalog No. ABIN5963314

Product Details anti-Desmocollin 2 Antibody

Target: Desmocollin 2 (DSC2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Desmocollin 2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human DSC2

Isotype: IgG

Application Details

Application Notes: WB 1:1000 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Desmocollin 2

Target: Desmocollin 2 (DSC2)

Alternative Name: DSC2 (DSC2 Products)

Synonyms: ARVD11 antibody, CDHF2 antibody, DG2 antibody, DGII/III antibody, DSC3 antibody, AW228162 antibody, Dsc2a antibody, Dsc2b antibody, DSC2 antibody, desmocollin 2 antibody, DSC2 antibody, Dsc2 antibody

Background:

Synonyms: ARVD11,Cadherin family member 2,CDHF2,Desmocollin 3,Desmocollin-2,Desmocollin-3,Desmocollin2,Desmosomal glycoprotein II and III,Desmosomal glycoprotein II,Desmosomal glycoprotein II/III,Desmosomal glycoprotein III,DG2,DGII/III,DKFZp686I11137,DSC 2,DSC2,DSC2,DSC3

Background: This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants.

Molecular Weight:

Observed_MW: 105kDa

Calculated_MW: 93kDa/99kDa

Gene ID: 1824

UniProt: Q02487