Uromodulin antibody
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- Target See all Uromodulin (UMOD) Antibodies
- Uromodulin (UMOD)
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Uromodulin antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purification
- Affinity purification
- Immunogen
- Recombinant protein of human UMOD
- Isotype
- IgG
- Top Product
- Discover our top product UMOD Primary Antibody
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- Application Notes
- WB 1:500 - 1:2000
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- Uromodulin (UMOD)
- Alternative Name
- UMOD (UMOD Products)
- Synonyms
- ADMCKD2 antibody, FJHN antibody, HNFJ antibody, HNFJ1 antibody, MCKD2 antibody, THGP antibody, THP antibody, urehr4 antibody, uromodulin antibody, UMOD antibody, Umod antibody
- Background
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Synonyms: ADMCKD2,FJHN,HNFJ,HNFJ1,MCKD2,medullary cystic kidney disease 2 (autosomal dominant),Tamm Horsfall glycoprotein,Tamm Horsfall urinary glycoprotein,Tamm-Horsfall urinary glycoprotein,THGP,THP,Umod,Urehd1,urehr4,UROM,uromodulin (uromucoid,Tamm-Horsfall glycoprotein),Uromodulin,Uromodulin,secreted form
Background: The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants.
- Molecular Weight
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Observed_MW: 70kDa
Calculated_MW: 55kDa/66kDa/67kDa/69kDa/73kDa
- Gene ID
- 7369
- UniProt
- P07911
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