SPTA1 antibody
-
- Target See all SPTA1 Antibodies
- SPTA1 (Spectrin alpha 1, Erythrocytic (SPTA1))
-
Reactivity
- Human, Mouse, Rat
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This SPTA1 antibody is un-conjugated
-
Application
- Immunohistochemistry (IHC), Immunofluorescence (IF)
- Purification
- Affinity purification
- Immunogen
- Recombinant fusion protein of human SPTA1 (NP_003117.2).
- Isotype
- IgG
- Top Product
- Discover our top product SPTA1 Primary Antibody
-
-
- Application Notes
- IHC 1:50-1:200 IF 1:50-1:200
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
-
- Target
- SPTA1 (Spectrin alpha 1, Erythrocytic (SPTA1))
- Alternative Name
- SPTA1 (SPTA1 Products)
- Synonyms
- Spna1 antibody, AF093576 antibody, AI451697 antibody, Spna-1 antibody, ha antibody, ihj antibody, nmf4 antibody, sph antibody, EL2 antibody, HPP antibody, HS3 antibody, SPH3 antibody, SPTA antibody, spectrin, alpha, erythrocytic 1 antibody, spectrin alpha, erythrocytic 1 antibody, Spta1 antibody, SPTA1 antibody
- Background
- Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.
- Molecular Weight
-
Observed_MW: 280kDa
Calculated_MW: 279kDa/280kDa
- Gene ID
- 6708
- UniProt
- P02549
- Pathways
- Regulation of Actin Filament Polymerization
-