AVEN antibody

Catalog No. ABIN5965750

Product Details anti-AVEN Antibody

Target: AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AVEN antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human AVEN (NP_065104.1).

Isotype: IgG

Application Details

Application Notes: WB 1:1000-1:3000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for AVEN

Target: AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))

Alternative Name: AVEN (AVEN Products)

Synonyms: AVEN antibody, pdcd12 antibody, aven antibody, wu:fc08c09 antibody, si:ch211-150c22.4 antibody, PDCD12 antibody, 1700013A01Rik antibody, 1700056A21Rik antibody, mAven-L antibody, mAven-S antibody, apoptosis and caspase activation inhibitor antibody, apoptosis, caspase activation inhibitor L homeolog antibody, apoptosis, caspase activation inhibitor antibody, Aven antibody, AVEN antibody, aven.L antibody, aven antibody

Background: AVEN, a cell death regulator, is an important signal inducer in acute leuke-mias. AVEN is a highly conserved peripheral membrane protein that protects the cell against the proteolytic activation of caspases as well as Apaf-1 mediated apoptosis by interfering with Apaf-1's ability to self-associate. Bcl-2 and Bad also interact with AVEN to prevent apoptosis. AVEN is highly expressed in ovary, heart, thymus, spleen, testis and colon, but can also be detected in other tissues. Erythropoietin and methylprednisolone may play important roles in the expression of AVEN in cardiac tissue, especially after a traumatic brain injury. In young patients suffering from acute lymphoblastic leukemia (ALL), AVEN expression may be a useful tool in prognosis prediction.

Molecular Weight:

Observed_MW: 55kDa

Calculated_MW: 38kDa

Gene ID: 57099

UniProt: Q9NQS1