AKR1C3 antibody
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- Target See all AKR1C3 Antibodies
- AKR1C3 (Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3))
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Reactivity
- Human, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This AKR1C3 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Purification
- Affinity purification
- Immunogen
- Recombinant protein of human AKR1C3
- Isotype
- IgG
- Top Product
- Discover our top product AKR1C3 Primary Antibody
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- Application Notes
- WB 1:500 - 1:2000 IHC 1:50 - 1:200
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- AKR1C3 (Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3))
- Alternative Name
- AKR1C3 (AKR1C3 Products)
- Synonyms
- AKR1C3 antibody, PGFS antibody, MGC134333 antibody, DD3 antibody, DDX antibody, HA1753 antibody, HAKRB antibody, HAKRe antibody, HSD17B5 antibody, hluPGFS antibody, Akr1c18 antibody, aldo-keto reductase family 1, member C3 L homeolog antibody, aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) antibody, aldo-keto reductase family 1 member C2 antibody, aldo-keto reductase family 1 member C3 antibody, aldo-keto reductase family 1, member C3 antibody, akr1c3.L antibody, AKR1C3 antibody, LOC722496 antibody, Akr1c3 antibody
- Background
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Synonyms: 17 beta HSD 5,17 beta hydroxysteroid dehydrogenase type 5,17-beta-HSD 5,17-beta-hydroxysteroid dehydrogenase type 5,2-dihydrobenzene-1,2-diol dehydrogenase,20-alpha-hydroxysteroid dehydrogenase,3 alpha hydroxysteroid dehydrogenase type II,3-alpha-HSD type 2,3-alpha-HSD type II,3-alpha-HSD type II,brain,3-alpha-hydroxysteroid dehydrogenase type 2,AK1C3,AKR1 C3,Akr1c18,AKR1C3,Aldo keto reductase family 1 member C3,Aldo-keto reductase family 1 member C3,brain,Chlordecone reductase,Chlordecone reductase homolog HAKRb,DD-3,DD3,DDH1,DDX,Dihydrodiol dehydrogenase 3,Dihydrodiol dehydrogenase type I,Dihydrodiol dehydrogenase X,HA1753,HAKRB,HAKRe,hluPGFS,HSD17B5,Indanol dehydrogenase,KIAA0119,PGFS,Prostaglandin F synthase,Testosterone 17-beta-dehydrogenase 5,Trans-1,Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase,Type IIb 3 alpha hydroxysteroid dehydrogenase
Background: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.
- Molecular Weight
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Observed_MW: 37kDa
Calculated_MW: 23kDa/36kDa
- Gene ID
- 8644
- UniProt
- P42330
- Pathways
- Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Biosynthesis, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, C21-Steroid Hormone Metabolic Process, Protein targeting to Nucleus
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