ORC1 antibody
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- Target See all ORC1 (ORC1L) Antibodies
- ORC1 (ORC1L) (Origin Recognition Complex, Subunit 1 (ORC1L))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ORC1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purification
- Affinity purification
- Immunogen
- Recombinant protein of human ORC1
- Isotype
- IgG
- Top Product
- Discover our top product ORC1L Primary Antibody
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- Application Notes
- WB 1:500 - 1:2000
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- ORC1 (ORC1L) (Origin Recognition Complex, Subunit 1 (ORC1L))
- Alternative Name
- ORC1 (ORC1L Products)
- Synonyms
- CG10667 antibody, DmORC1 antibody, DmOrc1 antibody, DmOrc1p antibody, Dmel\\CG10667 antibody, ORC antibody, ORC1 antibody, dORC1 antibody, orc1 antibody, rDmORC antibody, ORC1L antibody, HSORC1 antibody, PARC1 antibody, orc1l antibody, xorc1 antibody, AA545195 antibody, MmORC1 antibody, Orc1l antibody, Origin recognition complex subunit 1 antibody, origin recognition complex subunit 1 antibody, origin recognition complex subunit 1 L homeolog antibody, origin recognition complex, subunit 1 antibody, Orc1 antibody, ORC1 antibody, orc1.L antibody
- Background
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Synonyms: HSORC1,MmORC1,orc1,ORC1,ORC1L,Origin Recognition Complex 1,Origin recognition complex subunit 1 (yeast homolog) like,Origin recognition complex subunit 1,Origin recognition complex subunit 1 homolog,Origin recognition complex subunit 1 like (S. cerevisia,Origin recognition complex subunit 1 like,Origin recognition complex subunit 1 S. cerevisiae homolog like ,Origin recognition complex,subunit 1 like (yeast),PARC1,Replication control protein 1
Background: The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Molecular Weight
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Observed_MW: 90kDa
Calculated_MW: 97kDa
- Gene ID
- 4998
- UniProt
- Q13415
- Pathways
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
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