GEN1 antibody

Catalog No. ABIN5968265

Product Details anti-GEN1 Antibody

Target: GEN1 (Gen Endonuclease Homolog 1 (GEN1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GEN1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human GEN1

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for GEN1

Target: GEN1 (Gen Endonuclease Homolog 1 (GEN1))

Alternative Name: GEN1 (GEN1 Products)

Synonyms: 5830483C08Rik antibody, Gen antibody, RGD1559792 antibody, GEN1, Holliday junction 5' flap endonuclease antibody, GEN1 Holliday junction 5' flap endonuclease antibody, GEN1 antibody, Gen1 antibody

Background:

Synonyms: DKFZp781F0986,Flap endonuclease GEN homolog 1,FLJ40869,GEN 1,Gen,Gen homolog 1 endonuclease (Drosophila),Gen homolog 1 endonuclease,GEN,GEN1

Background: This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains. The protein encoded by this gene is involved in resolution of Holliday junctions, which are intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. The protein resolves Holliday junctions by creating dual incisions across the junction to produce nicked duplex products that can be ligated. In addition, this protein has been found to localize to centrosomes where it has been implicated in regulation of centrosome integrity. Alternative splicing results in multiple transcript variants.

Molecular Weight:

Observed_MW: 103kDa

Calculated_MW: 102kDa

Gene ID: 348654

UniProt: Q17RS7

Pathways: DNA Damage Repair