SPAG6 antibody (AA 180-290)

Catalog No. ABIN6133998

Product Details anti-SPAG6 Antibody

Target: SPAG6 (Sperm Associated Antigen 6 (SPAG6))

Binding Specificity: AA 180-290

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPAG6 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EIALKRIAAS ALSDIAKHSP ELAQTVVDAG AVAHLAQMIL NPDAKLKHQI LSALSQVSKH SVDLAEMVVE AEIFPVVLTC LKDKDEYVKK NASTLIREIA KHTPELSQLV V

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 180-290 of human SPAG6 (NP_758442.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SPAG6

Target: SPAG6 (Sperm Associated Antigen 6 (SPAG6))

Alternative Name: SPAG6 (SPAG6 Products)

Synonyms: Repro-SA-1 antibody, pf16 antibody, PF16 antibody, RGD1310892 antibody, zgc:91805 antibody, SPAG6 antibody, repro-sa-1 antibody, DKFZp459D035 antibody, sperm associated antigen 6 antibody, sperm associated antigen 6-like antibody, sperm associated antigen 6 L homeolog antibody, SPAG6 antibody, Spag6l antibody, Spag6 antibody, spag6 antibody, spag6.L antibody

Background: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene.,SPAG6,CT141,Repro-SA-1,pf16,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Microtubules,Stem Cells,Germline Stem Cells,SPAG6

Molecular Weight: 30 kDa/49 kDa/52 kDa/55 kDa/63 kDa

Gene ID: 9576

UniProt: O75602