MAPK8/9/10 antibody (pThr183, pThr221, Thr183)

Catalog No. ABIN6135990

Product Details anti-MAPK8/9/10 Antibody

Target: MAPK8/9/10 (Mitogen-Activated Protein Kinase 8/9/10 (MAPK8/9/10))

Binding Specificity: pThr183, pThr221, Thr183

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MAPK8/9/10 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Phosphorylated Antibodies

Immunogen: A phospho specific peptide corresponding to residues surrounding T183/T183/T221 of human JNK1/2/3

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MAPK8/9/10

Target: MAPK8/9/10 (Mitogen-Activated Protein Kinase 8/9/10 (MAPK8/9/10))

Alternative Name: MAPK8/MAPK9/MAPK10 (MAPK8/9/10 Products)

Background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016],JNK1/JNK2/JNK3,MAPK8/MAPK9/MAPK10

Molecular Weight: 35 kDa/44 kDa/48 kDa/27 kDa/52 kDa

Gene ID: 5599, 5601, 5602

UniProt: P45983, P45984, P53779