ABCC2 antibody (AA 180-315)

Catalog No. ABIN6136357

Product Details anti-ABCC2 Antibody

Target: ABCC2 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2))

Binding Specificity: AA 180-315

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: IFSAFSENNE SSNNPSSIAS FLSSITYSWY DSIILKGYKR PLTLEDVWEV DEEMKTKTLV SKFETHMKRE LQKARRALQR RQEKSSQQNS GARLPGLNKN QSQSQDALVL EDVEKKKKKS GTKKDVPKSW LMKALF

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 180-315 of human MRP2/ABCC2 (NP_000383.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ABCC2

Target: ABCC2 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2))

Alternative Name: ABCC2 (ABCC2 Products)

Synonyms: ABC30 antibody, CMOAT antibody, DJS antibody, MRP2 antibody, cMRP antibody, AI173996 antibody, Abc30 antibody, Cmoat antibody, Mrp2 antibody, ATP binding cassette subfamily C member 2 antibody, ATP-binding cassette, sub-family C (CFTR/MRP), member 2 antibody, ABCC2 antibody, Abcc2 antibody

Background: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine, therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.,ABCC2,ABC30,CMOAT,DJS,MRP2,cMRP,Cancer,Drug resistance,MRP-related proteins,Signal Transduction,Endocrine & Metabolism,ABCC2

Molecular Weight: 174 kDa

Gene ID: 1244

UniProt: Q92887

Pathways: Hormone Transport