Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Ataxin 1 antibody (AA 586-815)

ATXN1 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6137363
  • Target See all Ataxin 1 (ATXN1) Antibodies
    Ataxin 1 (ATXN1)
    Binding Specificity
    • 28
    • 20
    • 18
    • 11
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 586-815
    Reactivity
    • 77
    • 60
    • 36
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 65
    • 46
    • 1
    Rabbit
    Clonality
    • 66
    • 46
    Polyclonal
    Conjugate
    • 43
    • 8
    • 7
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This Ataxin 1 antibody is un-conjugated
    Application
    • 84
    • 46
    • 34
    • 33
    • 31
    • 23
    • 23
    • 22
    • 9
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    ELKKVEDLKT EDFIQSAEIS NDLKIDSSTV ERIEDSHSPG VAVIQFAVGE HRAQVSVEVL VEYPFFVFGQ GWSSCCPERT SQLFDLPCSK LSVGDVCISL TLKNLKNGSV KKGQPVDPAS VLLKHSKADG LAGSRHRYAE QENGINQGSA QMLSENGELK FPEKMGLPAA PFLTKIEPSK PAATRKRRWS APESRKLEKS EDEPPLTLPK PSLIPQEVKI CIEGRSNVGK
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 586-815 of human ATXN1 (NP_001121636.1).
    Isotype
    IgG
    Top Product
    Discover our top product ATXN1 Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    Ataxin 1 (ATXN1)
    Alternative Name
    ATXN1 (ATXN1 Products)
    Synonyms
    ATX1 antibody, D6S504E antibody, SCA1 antibody, ATXN1 antibody, ataxin 1b antibody, atxn1 antibody, 2900016G23Rik antibody, Atx1 antibody, C85907 antibody, ENSMUSG00000074917 antibody, Gm10786 antibody, Sca1 antibody, CG4547 antibody, Dmel\\CG4547 antibody, dAtx-1 antibody, dAtx1 antibody, sca1 antibody, ataxin 1 antibody, ataxin 1b antibody, Ataxin 1 antibody, ATXN1 antibody, atxn1b antibody, Atxn1 antibody, Atx-1 antibody
    Background
    The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 40-83 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene.,ATXN1,ATX1,D6S504E,SCA1,ataxin-1,Epigenetics & Nuclear Signaling,Signal Transduction,PI3K-Akt Signaling Pathway,Neuroscience,Neurodegenerative Diseases,ATXN1
    Molecular Weight
    86 kDa
    Gene ID
    6310
    UniProt
    P54253
    Pathways
    Synaptic Membrane
You are here:
Support