DAAM2 antibody (AA 1-86)

Catalog No. ABIN6139383

Product Details anti-DAAM2 Antibody

Target: DAAM2 (Dishevelled Associated Activator of Morphogenesis 2 (DAAM2))

Binding Specificity: AA 1-86

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DAAM2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: MAPRKRSHHG LGFLCCFGGS DIPEINLRDN HPLQFMEFSS PIPNAEELNI RFAELVDELD LTDKNREAMF ALPPEKKWQI YCSKKK

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-86 of human DAAM2 (NP_056160.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DAAM2

Target: DAAM2 (Dishevelled Associated Activator of Morphogenesis 2 (DAAM2))

Alternative Name: DAAM2 (DAAM2 Products)

Synonyms: dJ90A20A.1 antibody, 2310016D11Rik antibody, AI843643 antibody, AW557870 antibody, DAAM2 antibody, dishevelled associated activator of morphogenesis 2 antibody, DAAM2 antibody, Daam2 antibody, daam2 antibody

Background: Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1. Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly.,DAAM2,dJ90A20A.1,Stem Cells,DAAM2

Molecular Weight: 123 kDa

Gene ID: 23500

UniProt: Q86T65