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FAM208A antibody (AA 700-1000)

FAM208A Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6140453
  • Target
    FAM208A (Family with Sequence Similarity 208, Member A (FAM208A))
    Binding Specificity
    AA 700-1000
    Reactivity
    Human
    Host
    Rabbit
    Clonality
    Polyclonal
    Application
    Western Blotting (WB)
    Sequence
    DTEDMRSKTV LKRKLEDLPE NMRKLAKTSN LSENCHLYEE SPQPIGSLGH DADLRRQQQD TCNSGIADIH RLFNWLSETL ANARHSDASL TDTVNKALGL STDDAYEELR QKHEYELNST PDKKDYEQPT CAKVENAQFK GTQSLLLEVD ATSKYSVAIS TSEVGTDHKL HLKEDPNLIS VNNFEDCSLC PSVPIEHGFR RQQSKSNNVE ETEIHWKLIP ITGGNARSPE DQLGKHGEKQ TPGMKSPEEQ LVCVPPQEAF PNDPRVINRQ RSSDYQFPSS PFTDTLKGTT EDDVLTGQVE E
    Cross-Reactivity
    Human
    Characteristics
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 700-1000 of human FAM208A (NP_001106207.1).
    Isotype
    IgG
  • Application Notes
    WB,1:500 - 1:2000
    Comment

    HIGH QUALITY

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    FAM208A (Family with Sequence Similarity 208, Member A (FAM208A))
    Alternative Name
    FAM208A
    Synonyms
    c3orf63-a antibody, c3orf63.1 antibody, fam208a antibody, rap140 antibody, se89-1 antibody, C3orf63 antibody, RAP140 antibody, family with sequence similarity 208 member A L homeolog antibody, family with sequence similarity 208 member A antibody, fam208a.L antibody, FAM208A antibody
    Background
    Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2. Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. Plays a crucial role in early embryonic development (By similarity. Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity. Plays an important role in maintaining epiblast fitness or potency (By similarity.,FAM208A,C3orf63,RAP140,TASOR,se89-1,Epigenetics & Nuclear Signaling,RNA Binding,FAM208A
    Molecular Weight
    139 kDa/170 kDa/182 kDa/189 kDa
    Gene ID
    23272
    UniProt
    Q9UK61
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