GIPR antibody (AA 22-138)

Catalog No. ABIN6141096

Product Details anti-GIPR Antibody

Target: GIPR (Gastric Inhibitory Polypeptide Receptor (GIPR))

Binding Specificity: AA 22-138

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GIPR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: RAETGSKGQT AGELYQRWER YRRECQETLA AAEPPSGLAC NGSFDMYVCW DYAAPNATAR ASCPWYLPWH HHVAAGFVLR QCGSDGQWGL WRDHTQCENP EKNEAFLDQR LILERLQ

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 22-138 of human GIPR (NP_000155.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-GIPR antibody (ABIN6141096)

Ussher, Campbell, Mulvihill, Baggio, Bates, McLean, Gopal, Capozzi, Yusta, Cao, Ali, Kim, Kabir, Seino, Suzuki, Drucker: "Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction." in: Cell metabolism, Vol. 27, Issue 2, pp. 450-460.e6, (2018) (PubMed).

Target Details for GIPR

Target: GIPR (Gastric Inhibitory Polypeptide Receptor (GIPR))

Alternative Name: GIPR (GIPR Products)

Synonyms: GIPR antibody, PGQTL2 antibody, GIP-R antibody, Gm1081 antibody, Gm160 antibody, Gippr antibody, RATGIPPR antibody, gastric inhibitory polypeptide receptor antibody, glucagon receptor antibody, GIPR antibody, LOC100303705 antibody, Gipr antibody

Background: This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.,GIPR,PGQTL2,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Neuroscience,GIPR

Molecular Weight: 48 kDa/49 kDa/53 kDa

Gene ID: 2696

UniProt: P48546

Pathways: Positive Regulation of Peptide Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling