KCNJ3 antibody (AA 50-150)

Catalog No. ABIN6142731

Product Details anti-KCNJ3 Antibody

Target: KCNJ3 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3))

Binding Specificity: AA 50-150

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNJ3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: NGRCNVQHGN LGSETSRYLS DLFTTLVDLK WRWNLFIFIL TYTVAWLFMA SMWWVIAYTR GDLNKAHVGN YTPCVANVYN FPSAFLFFIE TEATIGYGYR Y

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human KCNJ3 (NP_002230.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for KCNJ3

Target: KCNJ3 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 (KCNJ3))

Alternative Name: KCNJ3 (KCNJ3 Products)

Synonyms: GIRK1 antibody, KGA antibody, KIR3.1 antibody, Kcnf3 antibody, Kir3.1 antibody, girk1 antibody, potassium voltage-gated channel subfamily J member 3 antibody, potassium inwardly-rectifying channel, subfamily J, member 3 antibody, KCNJ3 antibody, Kcnj3 antibody

Background: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins.,KCNJ3,GIRK1,KGA,KIR3.1,Neuroscience,Cardiovascular,Heart,Cardiac arrhythmias,KCNJ3

Molecular Weight: 26 kDa/56 kDa

Gene ID: 3760

UniProt: P48549