MSH3 antibody (AA 617-761)

Catalog No. ABIN6144059

Product Details anti-MSH3 Antibody

Target: MSH3 (MutS Homolog 3 (MSH3))

Binding Specificity: AA 617-761

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MSH3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: FNTSEEHHAD MYRSDLPNPD TLSAELHCWR IKWKHRGKDI ELPSTIYEAL HLPDIKFFPN VYALLKVLCI LPVMKVENER YENGRKRLKA YLRNTLTDQR SSNLALLNIN FDIKHDLDLM VDTYIKLYTS KSELPTDNSE TVENT

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 617-761 of human MSH3 (NP_004696.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MSH3

Target: MSH3 (MutS Homolog 3 (MSH3))

Alternative Name: MSH3 (MSH3 Products)

Synonyms: ATMSH3 antibody, M7J2.90 antibody, M7J2_90 antibody, homolog of DNA mismatch repair protein MSH3 antibody, DUP antibody, MRP1 antibody, D13Em1 antibody, Rep-3 antibody, Rep3 antibody, mutS homolog 3 antibody, DNA mismatch repair protein MSH3 antibody, homolog of DNA mismatch repair protein MSH3 antibody, mismatch repair protein antibody, MSH3 antibody, Msh3 antibody

Background: The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer.,MSH3,DUP,FAP4,MRP1,Epigenetics & Nuclear Signaling,DNA Damage & Repair,MSH3

Molecular Weight: 127 kDa

Gene ID: 4437

UniProt: P20585

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response