NCK2 antibody (AA 1-380)

Catalog No. ABIN6144407

Product Details anti-NCK2 Antibody

Target: NCK2 (NCK Adaptor Protein 2 (NCK2))

Binding Specificity: AA 1-380

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCK2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: MTEEVIVIAK WDYTAQQDQE LDIKKNERLW LLDDSKTWWR VRNAANRTGY VPSNYVERKN SLKKGSLVKN LKDTLGLGKT RRKTSARDAS PTPSTDAEYP ANGSGADRIY DLNIPAFVKF AYVAEREDEL SLVKGSRVTV MEKCSDGWWR GSYNGQIGWF PSNYVLEEVD EAAAESPSFL SLRKGASLSN GQGSRVLHVV QTLYPFSSVT EEELNFEKGE TMEVIEKPEN DPEWWKCKNA RGQVGLVPKN YVVVLSDGPA LHPAHAPQIS YTGPSSSGRF AGREWYYGNV TRHQAECALN ERGVEGDFLI RDSESSPSDF SVSLKASGKN KHFKVQLVDN VYCIGQRRFH TMDELVEHYK KAPIFTSEHG EKLYLVRALQ

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-380 of human NCK2 (NP_003572.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NCK2

Target: NCK2 (NCK Adaptor Protein 2 (NCK2))

Alternative Name: NCK2 (NCK2 Products)

Synonyms: GRB4 antibody, NCKbeta antibody, NCK2 antibody, 4833426I10Rik antibody, Grb4 antibody, Nck-2 antibody, Nck2 antibody, zgc:55283 antibody, fd20h08 antibody, im:7147817 antibody, si:ch211-147g19.3 antibody, wu:fd20h08 antibody, zgc:92024 antibody, NCK adaptor protein 2 antibody, cytoplasmic protein NCK2-like antibody, non-catalytic region of tyrosine kinase adaptor protein 2 antibody, NCK adaptor protein 2a antibody, NCK adaptor protein 2b antibody, NCK2 antibody, Nck2 antibody, LOC100227348 antibody, nck2a antibody, nck2b antibody

Background: This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.,NCK2,GRB4,NCKbeta,Epigenetics & Nuclear Signaling,Translation Control,Regulation of eIF2,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,Cell cycle inhibitors,Cytoskeleton,Microfilaments,Actins,Endocrine & Metabolism,Insulin Receptor Signaling Pathway,Immunology & Inflammation,T Cell Receptor Signaling Pathway,NCK2

Molecular Weight: 42 kDa

Gene ID: 8440

UniProt: O43639

Pathways: EGFR Signaling Pathway, Regulation of Actin Filament Polymerization