PDE6A antibody (AA 656-860)

Catalog No. ABIN6145361

Product Details anti-PDE6A Antibody

Target: PDE6A (phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A))

Binding Specificity: AA 656-860

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE6A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: EHAIHMMDIA IIATDLALYF KKRTMFQKIV DQSKTYESEQ EWTQYMMLEQ TRKEIVMAMM MTACDLSAIT KPWEVQSQVA LLVAAEFWEQ GDLERTVLQQ NPIPMMDRNK ADELPKLQVG FIDFVCTFVY KEFSRFHEEI TPMLDGITNN RKEWKALADE YDAKMKVQEE KKQKQQSAKS AAAGNQPGGN PSPGGATTSK SCCIQ

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 656-860 of human PDE6A (NP_000431.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PDE6A

Target: PDE6A (phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A))

Alternative Name: PDE6A (PDE6A Products)

Synonyms: si:bz1d10.3 antibody, si:rp71-1d10.3 antibody, CGPR-A antibody, PDEA antibody, RP43 antibody, Pdea antibody, nmf282 antibody, phosphodiesterase 6A, cGMP-specific, rod, alpha antibody, phosphodiesterase 6A antibody, pde6a antibody, PDE6A antibody, Pde6a antibody

Background: This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.,PDE6A,CGPR-A,PDEA,RP43,Signal Transduction,Neuroscience,PDE6A

Molecular Weight: 99 kDa

Gene ID: 5145

UniProt: P16499

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction