PLSCR1 antibody (AA 1-318)

Catalog No. ABIN6145796

Product Details anti-PLSCR1 Antibody

Target: PLSCR1 (phospholipid Scramblase 1 (PLSCR1))

Binding Specificity: AA 1-318

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLSCR1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MDKQNSQMNA SHPETNLPVG YPPQYPPTAF QGPPGYSGYP GPQVSYPPPP AGHSGPGPAG FPVPNQPVYN QPVYNQPVGA AGVPWMPAPQ PPLNCPPGLE YLSQIDQILI HQQIELLEVL TGFETNNKYE IKNSFGQRVY FAAEDTDCCT RNCCGPSRPF TLRIIDNMGQ EVITLERPLR CSSCCCPCCL QEIEIQAPPG VPIGYVIQTW HPCLPKFTIQ NEKREDVLKI SGPCVVCSCC GDVDFEIKSL DEQCVVGKIS KHWTGILREA FTDADNFGIQ FPLDLDVKMK AVMIGACFLI DFMFFESTGS QEQKSGVW

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-318 of human Phospholipid Scramblase 1 (Phospholipid Scramblase 1 (PLSCR1)) (NP_066928.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PLSCR1

Target: PLSCR1 (phospholipid Scramblase 1 (PLSCR1))

Alternative Name: PLSCR1 (PLSCR1 Products)

Synonyms: mmtra1b antibody, MGC84969 antibody, PLSCR1 antibody, MGC148322 antibody, MMTRA1B antibody, MmTRA1a antibody, MmTRA1b antibody, Nor1 antibody, Tra1 antibody, Tra1a antibody, Tra1b antibody, Tras1 antibody, Tras2 antibody, PLSCR2 antibody, phospholipid scramblase 1 L homeolog antibody, phospholipid scramblase 1 antibody, plscr1.L antibody, PLS1 antibody, PVX_111580 antibody, PLSCR1 antibody, plscr1 antibody, Plscr1 antibody, LOC100712949 antibody, PLSCR2 antibody, LOC100341366 antibody, LOC611500 antibody

Background: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (By similarity. Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A. Negatively regulates FcR-mediated phagocytosis in differentiated macrophages. May contribute to cytokine-regulated cell proliferation and differentiation (By similarity. May play a role in the antiviral response of interferon (IFN by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. Acts as an attachment receptor for HCV.,PLSCR1,MMTRA1B,Signal Transduction,Neuroscience,Calcium Signaling,Cardiovascular,Lipids,Lipoproteins/Apolipoproteins,PLSCR1

Molecular Weight: 26 kDa/35 kDa

Gene ID: 5359

UniProt: O15162

Pathways: Cellular Response to Molecule of Bacterial Origin