PTPRF antibody (AA 30-190)

Catalog No. ABIN6146462

Product Details anti-PTPRF Antibody

Target: PTPRF (Protein Tyrosine Phosphatase Receptor Type F (PTPRF))

Binding Specificity: AA 30-190

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPRF antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: DSKPVFIKVP EDQTGLSGGV ASFVCQATGE PKPRITWMKK GKKVSSQRFE VIEFDDGAGS VLRIQPLRVQ RDEAIYECTA TNSLGEINTS AKLSVLEEEQ LPPGFPSIDM GPQLKVVEKA RTATMLCAAG GNPDPEISWF KDFLPVDPAT SNGRIKQLRS G

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 30-190 of human PTPRF (NP_569707.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PTPRF

Target: PTPRF (Protein Tyrosine Phosphatase Receptor Type F (PTPRF))

Alternative Name: PTPRF (PTPRF Products)

Synonyms: LAR antibody, AA591035 antibody, LARS antibody, RPTP-LAR antibody, LARFN5C antibody, zf-LAR antibody, protein tyrosine phosphatase, receptor type F antibody, protein tyrosine phosphatase, receptor type, F antibody, protein tyrosine phosphatase, receptor type, f, a antibody, PTPRF antibody, Ptprf antibody, ptprfa antibody

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.,PTPRF,BNAH2,LAR,Cancer,Signal Transduction,Endocrine & Metabolism,Neuroscience,Cell Type Marker,Neuron marker,Synapse marker,PTPRF

Molecular Weight: 211 kDa/212 kDa

Gene ID: 5792

UniProt: P10586

Pathways: EGFR Signaling Pathway