Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificity
The antibody BRG-01 recognizes an epitope within C-terminal part of Human Brg1, a 205 kDa catalytic subunit of SWI2/SNF2-family chromatin-remodeling complexes.
Cross-Reactivity (Details)
Species reactivity (tested):Human
Purification
Protein-A affinity chromatography
Purity
> 95 % pure by SDS-PAGE
Immunogen
Bacterially produced GST-fused protein representing 242 C-terminal amino acids of human Brg1
Brg1 (Brahma-related gene 1) is an ATPase subunit of SWI2/SNF2-like chromatin-remodeling complexes that enable access of regulatory and effector proteins in transcription, DNA repair and DNA replication. Although Brg1-containing complexes are not essential for general cell survival, they participate in transcriptional regulation of several hundred genes including those involved in interferon and stress response, immune cells differentiation, neurogenesis, cell cycle etc. and is absolutely necessary for mouse embryogenesis. Brg1 is also involved in cell growth arrest, senescence and tumour supression.Synonyms: ATP-dependent helicase SMARCA4, BRG-1 protein, Brahma protein homolog 1, Mitotic growth and transcription activator, Probable global transcription activator SNF2L4, SNF2-beta, SNF2B, SNF2L4, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4