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MTR4 antibody (AA 1-304)

SKIV2L2 Reactivity: Human WB, IHC, IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6147814
  • Target See all MTR4 (SKIV2L2) Antibodies
    MTR4 (SKIV2L2) (Superkiller Viralicidic Activity 2-Like 2 (SKIV2L2))
    Binding Specificity
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-304
    Reactivity
    • 26
    • 15
    • 8
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 26
    Rabbit
    Clonality
    • 26
    Polyclonal
    Conjugate
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MTR4 antibody is un-conjugated
    Application
    • 15
    • 8
    • 7
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
    Sequence
    MADAFGDELF SVFEGDSTTA AGTKKDKEKD KGKWKGPPGS ADKAGKRFDG KLQSESTNNG KNKRDVDFEG TDEPIFGKKP RIEESITEDL SLADLMPRVK VQSVETVEGC THEVALPAEE DYLPLKPRVG KAAKEYPFIL DAFQREAIQC VDNNQSVLVS AHTSAGKTVC AEYAIALALR EKQRVIFTSP IKALSNQKYR EMYEEFQDVG LMTGDVTINP TASCLVMTTE ILRSMLYRGS EVMREVAWVI FDEIHYMRDS ERGVVWEETI ILLPDNVHYV FLSATIPNAR QFAEWICHLH KQPC
    Cross-Reactivity
    Human, Mouse
    Characteristics
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-304 of human SKIV2L2 (NP_056175.3).
    Isotype
    IgG
  • Application Notes
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IP,1:50 - 1:200
    Comment

    HIGH QUALITY

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    MTR4 (SKIV2L2) (Superkiller Viralicidic Activity 2-Like 2 (SKIV2L2))
    Alternative Name
    SKIV2L2 (SKIV2L2 Products)
    Synonyms
    RGD1305984 antibody, zgc:63838 antibody, wu:fd11a05 antibody, SKIV2L2 antibody, skiv2l2 antibody, Dob1 antibody, KIAA0052 antibody, Mtr4 antibody, fSAP118 antibody, 2610528A15Rik antibody, mKIAA0052 antibody, Ski2 like RNA helicase 2 antibody, superkiller viralicidic activity 2-like 2 antibody, superkiller viralicidic activity 2-like 2 (S. cerevisiae) antibody, Skiv2l2 antibody, skiv2l2 antibody, SKIV2L2 antibody, LOC100380870 antibody
    Background
    Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension. Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT and poly(A tail exosome targeting (PAXT. NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. PAXT directs a subset of long and polyadenylated poly(A RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor ZCCHC8, which links to RNA-binding protein adapters. Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA. May be involved in pre-mRNA splicing. In the context of NEXT complex can also in vitro unwind DNA:RNA heteroduplexes with a 3' poly (A RNA tracking strand. Can promote unwinding and degradation of structured RNA substrates when associated with the nuclear exosome and its cofactors. Can displace a DNA strand while translocating on RNA to ultimately degrade the RNA within a DNA/RNA heteroduplex. Plays a role in DNA damage response.,SKIV2L2,Dob1,KIAA0052,Mtr4,fSAP118,Epigenetics & Nuclear Signaling,RNA Binding,SKIV2L2
    Molecular Weight
    117 kDa
    Gene ID
    23517
    UniProt
    P42285
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