KIR2DL4/CD158d antibody (PE)

Catalog No. ABIN614806

Product Details anti-KIR2DL4/CD158d Antibody (PE)

Target: KIR2DL4/CD158d (KIR2DL4) (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KIR2DL4/CD158d antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Specificity: This antibody recognizes extracellular portion of CD158d / KIR2DL4, a 45 kDa NK cell marker. Cell surface expression and function of CD158d / KIR2DL4 depends on genotype of particular individuals.

Cross-Reactivity (Details): Species reactivity (tested):Human

Immunogen: NK3.3 cells and KIR2DL4-Ig fusion protein

Clone: MAb#33

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: DO NOT FREEZE! This product is photosensitive and should be protected from light.

Storage: 4 °C

Target Details for KIR2DL4/CD158d

Target: KIR2DL4/CD158d (KIR2DL4) (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4))

Alternative Name: CD158d / KIR2DL4 (KIR2DL4 Products)

Synonyms: G9P antibody, CD158D antibody, KIR103 antibody, KIR103AS antibody, KIR2DL4 antibody, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 antibody, killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 antibody, KIR2DL4 antibody

Background: CD158d / KIR2DL4 is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains cytoplasmic ITIM, suggesting inhibitory function, but also transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-γ secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G.Synonyms: CD158 antigen-like family member D, G9P, KIR103AS, Killer cell immunoglobulin-like receptor 2DL4, Killer cell inhibitory receptor 103AS, MHC class I NK cell receptor KIR103AS

Gene ID: 3805

NCBI Accession: NP_001074239

UniProt: Q99706