KIR2DL4/CD158d Products
(Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4))
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Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\\\\; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the 'framework' loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008].
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Featured KIR2DL4/CD158d Categories
KIR2DL4/CD158d Antibodies
High quality antibodies with extensive validation data.
KIR2DL4/CD158d Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended KIR2DL4/CD158d Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, FACS, IP, ICC
Validations
- (5)
- (4)
Cat. No.
ABIN509568
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, IP, ICC, Func
Validations
- (4)
Cat. No.
ABIN1302514
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (1)
- (3)
Cat. No.
ABIN652985
Quantity
400 μL
Datasheet
Datasheet
Recommended KIR2DL4/CD158d Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1308695
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3082557
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3082556
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our KIR2DL4/CD158d products
: "Possible Involvement of Human Mast Cells in the Establishment of Pregnancy via Killer Cell Ig-Like Receptor 2DL4." in: The American journal of pathology, Vol. 188, Issue 6, pp. 1497-1508, (2019) (PubMed).: "Killer cell immunoglobulin-like receptor 2DL4 is expressed in and suppresses the cell growth of Langerhans cell histiocytosis." in: Oncotarget, Vol. 8, Issue 23, pp. 36964-36972, (2017) (PubMed).
: "Activating KIR2DS4 Is Expressed by Uterine NK Cells and Contributes to Successful Pregnancy." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 11, pp. 4292-4300, (2017) (PubMed).
: "Genetic polymorphisms and expression of HLA-G and its receptors, KIR2DL4 and LILRB1, in non-small cell lung cancer." in: Tissue antigens, Vol. 85, Issue 6, pp. 466-75, (2015) (PubMed).
: "2DL1, 2DL2 and 2DL3 all contribute to KIR phenotype variability on human NK cells." in: Genes and immunity, Vol. 16, Issue 5, pp. 301-10, (2015) (PubMed).
: "Human cytomegalovirus infection elicits new decidual natural killer cell effector functions." in: PLoS pathogens, Vol. 9, Issue 4, pp. e1003257, (2014) (PubMed).
: "Killer Ig-like receptor 2DL4 does not mediate NK cell IFN-? responses to soluble HLA-G preparations." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 2, pp. 732-40, (2014) (PubMed).
: "TNFR-associated factor 6 and TGF-β-activated kinase 1 control signals for a senescence response by an endosomal NK cell receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 2, pp. 714-21, (2014) (PubMed).
: "HLA-G inhibition of NK-cell cytolytic function is uncoupled from tumor cell lipid raft reorganization." in: European journal of immunology, Vol. 42, Issue 3, pp. 700-9, (2012) (PubMed).
: "Decreased DNA methyltransferase levels contribute to abnormal gene expression in "senescent" CD4(+)CD28(-) T cells." in: Clinical immunology (Orlando, Fla.), Vol. 132, Issue 2, pp. 257-65, (2009) (PubMed).
Synonyms and alternative names related to KIR2DL4/CD158d
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 (KIR2DL4), CD158D, G9P, KIR2DL4, KIR103, KIR103ASProtein level used designations for KIR2DL4/CD158d
- CD158 antigen-like family member D
- KIR-103AS
- MHC class I NK cell receptor KIR103AS
- NK cell receptor
- killer Ig receptor
- killer cell immunoglobulin-like receptor 2DL4
- killer cell inhibitory receptor 103AS
- natural killer cell inhibitory receptor
- killer cell immunoglobulin-like receptor KIR2DL4
- killer cell immunogobulin-like receptor two domains long cytoplasmic tail 4
- killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
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