Ubinuclein 1 antibody (N-Term)

Catalog No. ABIN614815

This Mouse Monoclonal antibody specifically detects Ubinuclein 1 in WB and IP. It exhibits reactivity toward Human.

Quick Overview for Ubinuclein 1 antibody (N-Term) (ABIN614815)

Target: Ubinuclein 1 (UBN1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Ubinuclein 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: UBN1-02

Product Details anti-Ubinuclein 1 Antibody

Binding Specificity: AA 1-190, N-Term

Specificity: This antibody recognizes N-terminal part of ubinuclein 1 (UBN1), a widely expressed nuclear and adhesion complex protein. Western blotting analysis reveals UBN1 as a 165 kDa band.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein-A affinity chromatography

Purity: > 95 % pure by SDS-PAGE

Immunogen: Recombinant protein corresponding to amino acids 1-190 of ubinuclein 1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for Ubinuclein 1

Target: Ubinuclein 1 (UBN1)

Alternative Name: Ubinuclein-1 (UBN1)

Background: Ubinuclein 1 (UBN1) is a ubiquitously expressed evolutionarily conserved protein which binds to proliferation-promoting genes that are repressed by formation of senescence-associated heterochromatin foci (SAHF). Ubinuclein 1 associates with various transcription factors and with histone methyltransferase activity, is indispensable for SAHF formation and appears to be a regulator of senescence. Although in most cells ubinuclein is localized to the nucleus, in cells forming tight junctions it is recruited to the cell adhesion complexes, dependently on the cell density.Synonyms: HIRA-binding protein, Protein VT4, Ubiquitously expressed nuclear protein

Gene ID: 29855

NCBI Accession: NP_058632

UniProt: Q9NPG3