SMURF2 antibody (AA 150-250)

Catalog No. ABIN6148161

Product Details anti-SMURF2 Antibody

Target: SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))

Binding Specificity: AA 150-250

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMURF2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: DCSRLFDNDL PDGWEERRTA SGRIQYLNHI TRTTQWERPT RPASEYSSPG RPLSCFVDEN TPISGTNGAT CGQSSDPRLA ERRVRSQRHR NYMSRTHLHT P

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 150-250 of human SMURF2 (NP_073576.1).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SMURF2

Target: SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))

Alternative Name: SMURF2 (SMURF2 Products)

Synonyms: SMURF2 antibody, 2810411E22Rik antibody, AI558114 antibody, AI649275 antibody, RGD1310067 antibody, wu:fb82a11 antibody, wu:fc41c02 antibody, SMAD specific E3 ubiquitin protein ligase 2 antibody, SMAD specific E3 ubiquitin protein ligase 2 S homeolog antibody, SMURF2 antibody, smurf2 antibody, Smurf2 antibody, smurf2.S antibody

Background: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby downregulating TGF-beta signaling. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1. Also forms a stable complex with TGF-beta receptor-mediated phosphorylated SMAD1, SMAD2 and SMAD3, and targets SMAD1 and SMAD2 for ubiquitination and proteasome-mediated degradation. SMAD2 may recruit substrates, such as SNON, for ubiquitin-dependent degradation. Negatively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation.,SMURF2,Epigenetics & Nuclear Signaling,Signal Transduction,Cell Biology & Developmental Biology,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,TGF-b-Smad Signaling Pathway,Endocrine & Metabolism,Mitochondrial metabolism,Immunology & Inflammation,Stem Cells,SMURF2

Molecular Weight: 86 kDa

Gene ID: 64750

UniProt: Q9HAU4