Spindlin 1 antibody (AA 1-262)
-
- Target See all Spindlin 1 (SPIN1) Antibodies
- Spindlin 1 (SPIN1)
-
Binding Specificity
- AA 1-262
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This Spindlin 1 antibody is un-conjugated
-
Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- MKTPFGKTPG QRSRADAGHA GVSANMMKKR TSHKKHRSSV GPSKPVSQPR RNIVGCRIQH GWKEGNGPVT QWKGTVLDQV PVNPSLYLIK YDGFDCVYGL ELNKDERVSA LEVLPDRVAT SRISDAHLAD TMIGKAVEHM FETEDGSKDE WRGMVLARAP VMNTWFYITY EKDPVLYMYQ LLDDYKEGDL RIMPDSNDSP PAEREPGEVV DSLVGKQVEY AKEDGSKRTG MVIHQVEAKP SVYFIKFDDD FHIYVYDLVK TS
- Cross-Reactivity
- Human, Mouse, Rat
- Characteristics
- Polyclonal Antibodies
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-262 of human SPIN1 (NP_006708.2).
- Isotype
- IgG
- Top Product
- Discover our top product SPIN1 Primary Antibody
-
-
- Application Notes
- WB,1:500 - 1:2000,IHC,1:50 - 1:200
- Comment
-
HIGH QUALITY
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
-
- Target
- Spindlin 1 (SPIN1)
- Alternative Name
- SPIN1 (SPIN1 Products)
- Synonyms
- SPIN antibody, AA553322 antibody, AA673430 antibody, Spin antibody, spin antibody, spindlin antibody, MGC115436 antibody, Spindlin-1 antibody, DKFZp459K085 antibody, spindlin 1 antibody, spindlin 1 L homeolog antibody, SPIN1 antibody, Spin1 antibody, spin1 antibody, spin1.L antibody
- Background
- Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway. Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes. May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.,SPIN1,SPIN,TDRD24,Epigenetics & Nuclear Signaling,Cancer,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,SPIN1
- Molecular Weight
- 29 kDa
- Gene ID
- 10927
- UniProt
- Q9Y657
-