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CXCR4 antibody (Extracellular Domain, N-Term)
CXCR4
Reactivity: Human, Mouse, Xenopus laevis
WB, IHC (p), EIA
Host: Goat
Polyclonal
unconjugated
Product Details anti-CXCR4 Antibody
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Target
See all CXCR4 Antibodies
CXCR4
(Chemokine (C-X-C Motif) Receptor 4 (CXCR4))
Binding Specificity
All epitopes for CXCR4 antibodies
AA 14-40, Extracellular Domain, N-Term
Reactivity
All reactivities for CXCR4 antibodies
Human, Mouse, Xenopus laevis
Host
All hosts for CXCR4 antibodies
Goat
Clonality
All clonalities for CXCR4 antibodies
Polyclonal
Conjugate
All conjugates for CXCR4 antibodies
This CXCR4 antibody is un-conjugated
Application
All applications for CXCR4 antibodies
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
Sequence
YSEEVGSGDY DSNKEPCFRD ENVHFNR
Specificity
This antibody binds to CXCR4 receptor on Mouse spleen leukocytes as determined by Immunocytochemistry.
Cross-Reactivity (Details)
Species reactivity (expected):Xenopus, Human. Species reactivity (tested):Mouse
Purification
Immunoaffinity Chromatography
Immunogen
Sequence corresponding to the N-terminal extracellular domain of Mouse CXCR4 receptor. Epitope: aa14-40 Genename: CXCR4
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Discover our top product CXCR4 Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
1.0 mg/mL
Buffer
PBS, 0.09 % Sodium Azide, 1 mg/mL BSA
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for CXCR4
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Target
CXCR4
(Chemokine (C-X-C Motif) Receptor 4 (CXCR4))
Alternative Name
CD184 / CXCR4 (CXCR4 Products )
Synonyms
CD184 antibody, D2S201E antibody, FB22 antibody, HM89 antibody, HSY3RR antibody, LAP3 antibody, LCR1 antibody, LESTR antibody, NPY3R antibody, NPYR antibody, NPYRL antibody, NPYY3R antibody, WHIM antibody, Cmkar4 antibody, PB-CKR antibody, PBSF/SDF-1 antibody, Sdf1r antibody, CXC-R4-B antibody, CXCR-4-B antibody, cd184 antibody, cxcr4 antibody, fb22 antibody, hm89 antibody, hsy3rr antibody, lap3 antibody, lcr1 antibody, lestr antibody, npy3r antibody, npyr antibody, npyrl antibody, npyy3r antibody, xcxcr4 antibody, CXC-R4 antibody, CXCR-4 antibody, d2s201e antibody, whim antibody, CXC-R4-A antibody, CXCR-4-A antibody, xCXCR4 antibody, CXCR4 antibody, cb403 antibody, zgc:109863 antibody, cb824 antibody, C-X-C motif chemokine receptor 4 antibody, chemokine (C-X-C motif) receptor 4 antibody, C-X-C motif chemokine receptor 4 S homeolog antibody, C-X-C chemokine receptor type 4 antibody, C-X-C motif chemokine receptor 4 L homeolog antibody, chemokine (C-X-C motif), receptor 4b antibody, chemokine (C-X-C motif) receptor 4a antibody, CXCR4 antibody, Cxcr4 antibody, cxcr4.S antibody, cxcr4 antibody, LOC100049444 antibody, cxcr4.L antibody, cxcr4b antibody, cxcr4a antibody
Background
CXCR4, a Chemokine Receptor involved in organ vascularization, neuronal cell migration, and patterning of the central nervous system during development. It binds stromal cell-derived factor 1 (SDF1, also called PBFS) and mediates migration of resting leukocytes and is unique in homing hematopoietic progenitors to bone marrow. These properties suggest that CXCR4 is involved in tumor cell migration and local tumor invasion. It is also an HIV-1 fusion co-factor that allows HIV-1 invasion in diverse human cell types. Although this receptor was initially called Neuropeptide Y3 Receptor, it does not respond to neuropeptide Y. CXCR4 has two isoforms that are produced by alternative splicing.Synonyms: C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, FB22, Fusin, HM89, LCR1, LESTR, Leukocyte-derived seven transmembrane domain receptor, NPYRL, SDF1 receptor, Stromal cell-derived factor 1 receptor
Gene ID
7852
NCBI Accession
NP_001008540
UniProt
P61073
Pathways
Regulation of Cell Size , CXCR4-mediated Signaling Events
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