UQCRFS1 antibody (AA 79-274)

Catalog No. ABIN6149963

Product Details anti-UQCRFS1 Antibody

Target: UQCRFS1 (Ubiquinol-Cytochrome C Reductase, Rieske Iron-Sulfur Polypeptide 1 (UQCRFS1))

Binding Specificity: AA 79-274

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UQCRFS1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: SHTDIKVPDF SEYRRLEVLD STKSSRESSE ARKGFSYLVT GVTTVGVAYA AKNAVTQFVS SMSASADVLA LAKIEIKLSD IPEGKNMAFK WRGKPLFVRH RTQKEIEQEA AVELSQLRDP QHDLDRVKKP EWVILIGVCT HLGCVPIANA GDFGGYYCPC HGSHYDASGR IRLGPAPLNL EVPTYEFTSD DMVIVG

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 79-274 of human UQCRFS1 (NP_005994.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-UQCRFS1 antibody (ABIN6149963)

Hu, Nie, Chen, Xie, Fan, Wang, Long, Yan, Zhong, Yan: "Leucine reduces reactive oxygen species levels via an energy metabolism switch by activation of the mTOR-HIF-1α pathway in porcine intestinal epithelial cells." in: The international journal of biochemistry & cell biology, Vol. 89, pp. 42-56, (2017) (PubMed).

Target Details for UQCRFS1

Target: UQCRFS1 (Ubiquinol-Cytochrome C Reductase, Rieske Iron-Sulfur Polypeptide 1 (UQCRFS1))

Alternative Name: UQCRFS1 (UQCRFS1 Products)

Synonyms: uqcrfs1 antibody, MGC53134 antibody, rip1 antibody, ris1 antibody, risp antibody, uqcr5 antibody, fb78f10 antibody, wu:fb05d11 antibody, wu:fb78f10 antibody, wu:fj05e12 antibody, zgc:73109 antibody, zgc:85614 antibody, GLEAN_00043 antibody, RIP1 antibody, RIS1 antibody, RISP antibody, UQCR5 antibody, 4430402G14Rik antibody, AI875505 antibody, LRRGT00195 antibody, UQCRFSL1 antibody, ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 S homeolog antibody, ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 antibody, cytochrome b-c1 complex subunit Rieske, mitochondrial antibody, iron-sulfur protein 1 antibody, uqcrfs1.S antibody, uqcrfs1 antibody, LOC661125 antibody, LOC705178 antibody, UQCRFS1 antibody, Uqcrfs1 antibody, LOC100227575 antibody, isp1 antibody

Background: [Cytochrome b-c1 complex subunit Rieske, mitochondrial]: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII, ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII and cytochrome c oxidase (complex IV, CIV, that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0 site in cytochrome b to cytochrome c1 (By similarity. Incorporation of UQCRFS1 is the penultimate step in complex III assembly.,UQCRFS1,RIP1,RIS1,RISP,UQCR5,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,Oxidative phosphorylation,Neuroscience,Neurodegenerative Diseases,UQCRFS1

Molecular Weight: 29 kDa

Gene ID: 7386

UniProt: P47985

Pathways: Proton Transport