XBP1 antibody (AA 1-261)
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- Target See all XBP1 Antibodies
- XBP1 (X-Box Binding Protein 1 (XBP1))
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Binding Specificity
- AA 1-261
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This XBP1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- MVVVAAAPNP ADGTPKVLLL SGQPASAAGA PAGQALPLMV PAQRGASPEA ASGGLPQARK RQRLTHLSPE EKALRRKLKN RVAAQTARDR KKARMSELEQ QVVDLEEENQ KLLLENQLLR EKTHGLVVEN QELRQRLGMD ALVAEEEAEA KGNEVRPVAG SAESAALRLR APLQQVQAQL SPLQNISPWI LAVLTLQIQS LISCWAFWTT WTQSCSSNAL PQSLPAWRSS QRSTQKDPVP YQPPFLCQWG RHQPSWKPLM N
- Cross-Reactivity
- Human, Mouse, Rat
- Characteristics
- Polyclonal Antibodies
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-261 of human XBP1 (NP_005071.2).
- Isotype
- IgG
- Top Product
- Discover our top product XBP1 Primary Antibody
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- Application Notes
- WB,1:500 - 1:2000
- Comment
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HIGH QUALITY
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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The TRiC chaperonin controls reovirus replication through outer-capsid folding." in: Nature microbiology, Vol. 3, Issue 4, pp. 481-493, (2018) (PubMed).
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The TRiC chaperonin controls reovirus replication through outer-capsid folding." in: Nature microbiology, Vol. 3, Issue 4, pp. 481-493, (2018) (PubMed).
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- Target
- XBP1 (X-Box Binding Protein 1 (XBP1))
- Alternative Name
- XBP1 (XBP1 Products)
- Synonyms
- treb5 antibody, xXBP1 antibody, xbp2 antibody, XBP1P1 antibody, XBPP1 antibody, xbp1 antibody, TREB5 antibody, XBP-1 antibody, XBP2 antibody, D11Ertd39e antibody, TREB-5 antibody, HTF antibody, cb918 antibody, id:ibd1195 antibody, trebf antibody, wu:fb02h05 antibody, wu:fb63f10 antibody, xbp1a antibody, xbp1b antibody, X-box binding protein 1 antibody, X-box binding protein 1 L homeolog antibody, xbp1 antibody, XBP1 antibody, Xbp1 antibody, xbp1.L antibody
- Background
- This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.,XBP1,TREB-5,TREB5,XBP-1,XBP2,XBP1s,CBX1,Epigenetics & Nuclear Signaling,Transcription Factors,XBP1
- Molecular Weight
- 28 kDa/40 kDa
- Gene ID
- 7494
- UniProt
- P17861
- Pathways
- ER-Nucleus Signaling, Unfolded Protein Response
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