Desmoglein 2 antibody (CF®405S)
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- Target See all Desmoglein 2 (DSG2) Antibodies
- Desmoglein 2 (DSG2)
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Desmoglein 2 antibody is conjugated to CF®405S
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Application
- Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)
- Purpose
- Mouse Monoclonal anti-Desmoglein-2 (8-E5), CF405S Conjugate
- Characteristics
- This antibody recognizes the extracellular domain of human desmoglein-2 (DSG2), a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Human Desmoglein-2 is a type I transmembrane glycoprotein of 1117 amino acid (aa) residues with a 23 aa signal peptide and a 25 aa propeptide. It differs from other classic cadherins by having four instead of five cadherin repeat domains in its extracellular region, and a much larger cytoplasmic region containing five desmoglein repeat domains which share homology with the cadherin repeats. Desmoglein-2 has been shown to be important in establishing cell-cell adhesion and function in epithelial cells. It was originally identified in colon carcinoma and colon, and was named HDGC (human desmoglein colon). Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Immunogen
- Recombinant human full-length DSG2 protein
- Clone
- 8 E5
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product DSG2 Primary Antibody
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- Application Notes
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Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Immunofluorescence 1-2 μg/mL
- Western blotting 0.5-1 μg/mL
- Optimal dilution for a specific application should be determined by user
- Comment
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A431, HepG2 or K562 cells. Heart or Colon
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 100 μg/mL
- Buffer
- PBS/0.1 % BSA/0.05 % azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Protect from light
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- Target
- Desmoglein 2 (DSG2)
- Alternative Name
- Desmoglein-2 (DSG2 Products)
- Synonyms
- DSG2 antibody, dsc antibody, dsga antibody, si:dkeyp-51f12.6 antibody, wu:fj23f02 antibody, ARVC10 antibody, ARVD10 antibody, CDHF5 antibody, CMD1BB antibody, HDGC antibody, AA408168 antibody, D18Ertd293e antibody, desmoglein 2 antibody, desmoglein 2, tandem duplicate 1 antibody, DSG2 antibody, dsg2.1 antibody, dsg2 antibody, Dsg2 antibody
- Background
- ARVC10, ARVD10, Cadherin family member 5, CDHF5, CMD1BB, Desmoglein-2, DSG2, HDGC, Human Desmoglein Colon
- Molecular Weight
- ~165 kDa
- Gene ID
- 1829, 412597
- UniProt
- Q14126
- Pathways
- Cell-Cell Junction Organization
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