Transgelin antibody (CF®488A)
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- Target See all Transgelin (TAGLN) Antibodies
- Transgelin (TAGLN)
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Reactivity
- Human, Mouse, Cow, Rabbit, Pig
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Transgelin antibody is conjugated to CF®488A
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Application
- Flow Cytometry (FACS), Immunofluorescence (IF)
- Purpose
- Mouse Monoclonal anti-Transgelin / SM22-alpha (TAGLN/247), CF488A Conjugate
- Characteristics
- This MAb recognizes a 22 kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Immunogen
- Recombinant full-length human transgelin (TAGLN) protein.
- Clone
- TAGLN-247
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product TAGLN Primary Antibody
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- Application Notes
- Flow Cytometry 0.5-1 μg/million cells/0.1 mLImmunofluorescence 1-2 μg/mL
- Comment
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U-2 OS, Hs68 or WI 38 cells. Colon carcinoma.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 100 μg/mL
- Buffer
- PBS/0.1 % BSA/0.05 % azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Protect from light
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- Target
- Transgelin (TAGLN)
- Alternative Name
- Transgelin / SM22-alpha (TAGLN Products)
- Synonyms
- MGC68550 antibody, sm22 antibody, smcc antibody, tagln1 antibody, ws3-10 antibody, MGC107855 antibody, SM22 antibody, SMCC antibody, TAGLN1 antibody, WS3-10 antibody, Sm22 antibody, Sm22a antibody, Ws310 antibody, SM22A antibody, zgc:153186 antibody, transgelin L homeolog antibody, transgelin antibody, tagln.L antibody, tagln antibody, LOC732906 antibody, TAGLN antibody, tagl antibody, LOC100009332 antibody, Tagln antibody
- Molecular Weight
- 22 kDa
- Gene ID
- 6876, 410977
- UniProt
- Q01995
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