PLGF antibody (CF®405S)

Catalog No. ABIN6189233

Product Details anti-PLGF Antibody (CF®405S)

Target: PLGF (PGF) (Placenta Growth Factor (PGF))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PLGF antibody is conjugated to CF®405S

Application: ELISA, Coating (Coat)

Purpose: Mouse Monoclonal anti-PLGF (PLGF/94), CF405S Conjugate

Characteristics: The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include Fibroblast Growth Factor (FGF), Platelet Derived Growth Factor (PDGF), Vascular Endothelial Growth Factor (VEGF) and Placenta Growth Factor (PLGF). Placenta growth factor (PLGF) is a secreted protein primarily produced by placental trophoblasts but also expressed in other endothelial cells and tumors. There are three isoforms, PLGF-1, PLGF-2, and PLGF-3. PLGF-2 is expressed up until week 8 in the placenta, the placental tissues continuously express PLGF-1 and PLGF-3 but only PLGF-1 is found in colon and mammary carcinomas. PLGF acts to stimulate angiogenesis, endothelial growth and migration. PLGF is a powerful promoter of tumor growth and is upregulated in some cancers, and PLGF is thought to aid in atherosclerotic lesions and neovascular growth surrounding the lesion. Also, PLGF appears to aid aldosterone mediated atherosclerosis. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant human PLGF protein

Clone: PLGF94

Isotype: IgG1 kappa

Application Details

Application Notes: ELISA For coating, order Ab without BSA

Comment:

HepG2 or HEK293T cells. Human placental and brain tumors.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Target Details for PLGF

Target: PLGF (PGF) (Placenta Growth Factor (PGF))

Alternative Name: PLGF (PGF Products)

Synonyms: D12S1900 antibody, PGFL antibody, PLGF antibody, PlGF-2 antibody, SHGC-10760 antibody, AI854365 antibody, PIGF antibody, Plgf antibody, PlGF antibody, placental growth factor antibody, placenta growth factor antibody, PGF antibody, Pgf antibody, PLGF antibody

Background: PGFL, PIGF, placental growth factor (PGF), Vascular endothelial growth factor related protein

Molecular Weight: 18 kDa

Gene ID: 5228, 252820

UniProt: P49763

Pathways: VEGFR1 Specific Signals