Complement Factor H antibody (AA 270-445)

Catalog No. ABIN6217773

Product Details anti-Complement Factor H Antibody

Target: Complement Factor H (CFH)

Binding Specificity: AA 270-445

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Complement Factor H antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PYIPNGDYSP LRIKHRTGDE ITYQCRNGFY PATRGNTAKC TSTGWIPAPR CTLKPCDYPD IKHGGLYHEN MRRPYFPVAV GKYYSYYCDE HFETPSGSYW DHIHCTQDGW SPAVPCLRKC YFPYLENGYN QNHGRKFVQG KSIDVACHPG YALPKAQTTV TCMENGWSPT PRCIRV

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 270-445 of human Complement factor H (NP_001014975.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Complement Factor H

Target: Complement Factor H (CFH)

Alternative Name: CFH (CFH Products)

Synonyms: AHUS1 antibody, AMBP1 antibody, ARMD4 antibody, ARMS1 antibody, CFHL3 antibody, FH antibody, FHL1 antibody, HF antibody, HF1 antibody, HF2 antibody, HUS antibody, Mud-1 antibody, NOM antibody, Sas-1 antibody, Sas1 antibody, Fh antibody, CFH antibody, im:7147412 antibody, si:ch211-207o17.2 antibody, fH antibody, armd4 antibody, arms1 antibody, cfh antibody, cfhl3 antibody, fhl1 antibody, hf1 antibody, hf2 antibody, hus antibody, complement factor H antibody, complement component factor h antibody, complement factor H-related protein 5 antibody, complement factor H L homeolog antibody, CFH antibody, Cfh antibody, cfh antibody, LOC100399888 antibody, LOC100733902 antibody, cfh.L antibody

Background: This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.,CFH,AHUS1,AMBP1,ARMD4,ARMS1,CFHL3,FH,FHL1,HF,HF1,HF2,HUS,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,CFH

Molecular Weight: 51 kDa/139 kDa

Gene ID: 3075

UniProt: P08603

Pathways: Complement System, Cellular Response to Molecule of Bacterial Origin