GZMB antibody

Catalog No. ABIN6241151

This Rabbit Polyclonal antibody specifically detects GZMB in WB and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for GZMB antibody (ABIN6241151)

Target: GZMB (Granzyme B (GZMB))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GZMB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-GZMB Antibody

Immunogen: Synthetic Peptide

Application Details

Application Notes: WB: 1:1000. IHC: 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: 4 °C,-20 °C

Target Details for GZMB

Target: GZMB (Granzyme B (GZMB))

Alternative Name: Granzyme B

Background: This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

UniProt: P10144

Pathways: Apoptosis, Caspase Cascade in Apoptosis