This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This HIST1H2BM antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 10-44 amino acids from the N-terminal region of human HIST1H2BM.
H2B/e antibody, H2BFE antibody, dJ160A22.3 antibody, H2b-291b antibody, histone cluster 1 H2B family member m antibody, histone cluster 1, H2bm antibody, HIST1H2BM antibody, Hist1h2bm antibody
Background
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.