ATG10 antibody (N-Term)

Catalog No. ABIN6244154

Product Details anti-ATG10 Antibody

Target: ATG10 (Autophagy Related 10 (ATG10))

Binding Specificity: AA 15-45, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATG10 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This ATG10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15~45 amino acids from the N-term of human APG10L.

Clone: RB7550

Isotype: Ig Fraction

Application Details

Application Notes: IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-ATG10 antibody (ABIN6244154)

Sanchez, Penfornis, Oskowitz, Boonjindasup, Cai, Dhule, Rowan, Kelekar, Krause, Pochampally: "Activation of autophagy in mesenchymal stem cells provides tumor stromal support." in: Carcinogenesis, Vol. 32, Issue 7, pp. 964-72, (2011) (PubMed).

Target Details for ATG10

Target: ATG10 (Autophagy Related 10 (ATG10))

Alternative Name: ATG10 (ATG10 Products)

Synonyms: APG10 antibody, APG10L antibody, pp12616 antibody, Atg10 antibody, ATG10 antibody, MGC123341 antibody, im:7153729 antibody, zgc:123341 antibody, ATATG10 antibody, autophagy 10 antibody, DDBDRAFT_0190076 antibody, DDBDRAFT_0252608 antibody, DDB_0190076 antibody, DDB_0252608 antibody, 5330424L23Rik antibody, 5430428K15Rik antibody, AI852123 antibody, Agp10 antibody, Apg10l antibody, Apg10p antibody, Atg10l antibody, autophagy related 10 antibody, autophagy-related 10 antibody, AuTophaGy (yeast Atg homolog) antibody, ATG10 autophagy related 10 homolog (S. cerevisiae) antibody, autophagocytosis-associated family protein antibody, E2-like conjugating enzyme antibody, hypothetical protein antibody, autophagy protein 10 antibody, autophagy-related protein 10 antibody, ATG10 antibody, Atg10 antibody, atg-10 antibody, atg10 antibody, CAALFM_C302930WA antibody, APG10 antibody

Background: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG10 is an ATG12-conjugating enzyme (E2-like enzyme) that likely serves as an ATG5-recognition molecule. This protein interacts with MAP1LC3A. By interacting with MAP1LC3A, it plays a role in the conjugation of ATG12 to ATG5. APG10 also is able to directly interact either with ATG5 or ATG7.

Molecular Weight: 25279

NCBI Accession: NP_001124500, NP_113670

UniProt: Q9H0Y0

Pathways: ER-Nucleus Signaling, Autophagy