S100A8 antibody (N-Term)

Catalog No. ABIN6251942

The Mouse Monoclonal anti-S100A8 antibody (Clone SA6279) (ABIN6251942) specifically detects S100A8 in WB. The antibody is reactive with Human samples.

Quick Overview for S100A8 antibody (N-Term) (ABIN6251942)

Target: S100A8 (S100 Calcium Binding Protein A8 (S100A8))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This S100A8 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: SA6279

Product Details anti-S100A8 Antibody

Binding Specificity: N-Term

Purification: Protein G affinity chromatography

Immunogen: A recombinant protein fragment from the N-terminal region of human S100A8 was used as the immunogen for this antibody.

Isotype: IgG1 kappa

Application Details

Application Notes: Western blot: 2-4 μg/mL

Provided assay concentrations are suggestions only, S100A8 antibody titration may be required for optimal results.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.1 mg/mL BSA and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot and Store at -20C. Avoid freez-thaw cycles.

Target Details for S100A8

Target: S100A8 (S100 Calcium Binding Protein A8 (S100A8))

Alternative Name: S100A8

Background: The S100 family of proteins are found in vertebrates and are characterized by two calcium-binding sites that have a helix-loop-helix conformation. The family of 24 is divided into three subgroups based on function: those with intracellular, intracellular plus extracellular, and extracellular regulatory effects. The calcium-binding protein S100A8, also called MRP8 or Myeloid-related protein 8, and Calgranulin A, forms a heterodimer with S100A9, called Calprotectin. The heterodimer is expressed by granulocytes, monocytes, and early differentiation states of macrophages, and is known to be an important pro-inflammatory mediator in acute and chronic inflammation. S100A8 and 9 are DAMPs, or Damage-associated molecular pattern molecules, and are able to activate receptors of the innate immune system, one being TLR4.

Gene ID: 6279

UniProt: P05109

Pathways: Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity, S100 Proteins