CRHR2 antibody (N-Term)

Catalog No. ABIN6252313

The Rabbit Polyclonal anti-CRHR2 antibody is suitable to detect CRHR2 in samples from Human, Rat and Mouse. It has been validated for WB.

Quick Overview for CRHR2 antibody (N-Term) (ABIN6252313)

Target: CRHR2 (Corticotropin Releasing Hormone Receptor 2 (CRHR2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRHR2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CRHR2 Antibody

Binding Specificity: N-Term

Purification: Protein A affinity chromatography

Immunogen: A recombinant protein fragment from the N-terminal portion of human CRHR2 was used as the immunogen for this antibody (1).

Isotype: IgG

Application Details

Application Notes: Western blot: 0.5-2 μg/mL

Provided assay concentrations are suggestions only, CRHR2 antibody titration may be required for optimal results.

1. This antibody will detect the alpha (411 AA), beta (438 AA) and gamma (397 AA) isoforms of CRHR2.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.1 mg/mL BSA and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot and Store at -20C. Avoid freez-thaw cycles.

Target Details for CRHR2

Target: CRHR2 (Corticotropin Releasing Hormone Receptor 2 (CRHR2))

Alternative Name: CRHR2

Background: CHCR2, or Corticotropin releasing hormone receptor 2, is a receptor for CRH (corticotropin-releasing hormone), a neurotransmitter secreted by the hypothalamus in response to stress. There are three major isoforms of CHCR2: alpha, beta and gamma, differing in their N-terminus amino acid sequence. Isoform beta and gamma are expressed in the brain, with gamma expression highest in the septum and hippocampus, while alpha is expressed in the peripheral tissues of the brain.

Gene ID: 1395

UniProt: Q13324

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Feeding Behaviour