TGF-beta antibody
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- Target See all TGF-beta (TGFb) Antibodies
- TGF-beta (TGFb)
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Reactivity
- Human, Mouse, Rat, Cow, Dog, Hamster, Monkey
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This TGF-beta antibody is un-conjugated
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Application
- Neutralization (Neut)
- Purification
- Protein G affinity chromatography
- Immunogen
- Bovine TGF-beta2 protein was used as the immunogen for the TGF-beta antibody.
- Clone
- 1D11-16-8
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product TGFb Primary Antibody
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- Application Notes
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Functional Activity: Cytokine Neutralization (Order SAF formulation)
Optimal dilution of the TGF-beta antibody should be determined by the researcher. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.2 mg/mL
- Buffer
- PBS with 0.1 mg/mL BSA and 0.05 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Aliquot and Store at -20C. Avoid freez-thaw cycles.
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- Target
- TGF-beta (TGFb)
- Alternative Name
- TGF-beta (TGFb Products)
- Synonyms
- CED antibody, DPD1 antibody, LAP antibody, TGFB antibody, TGFbeta antibody, TGF-beta antibody, TGF-BETA-1 antibody, TGF-beta1 antibody, TGFbeta1 antibody, Tgfb antibody, Tgfb-1 antibody, transforming growth factor beta 1 antibody, transforming growth factor beta-1 antibody, transforming growth factor, beta 1 antibody, TGFB1 antibody, Tgfb1 antibody
- Background
- This mAb recognizes TGF beta 1, 2 and 3. Three TGFbs have been identified in mammals. TGFb1, TGFb2 and TGFb3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFb requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFb3 protein has approximately 80 % identity to the mature region of both TGFb1 and TGFb2. However, the NH2 terminals or precursor regions of their molecules share only 27 % sequence identity. TGFb's inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.
- Gene ID
- 7040, 7043, 7042
- UniProt
- P01137, P10600, P61812
- Pathways
- EGFR Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus
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