FTL antibody (AA 38-165)

Catalog No. ABIN6252862

Product Details anti-FTL Antibody

Target: FTL (Ferritin, Light Polypeptide (FTL))

Binding Specificity: AA 38-165

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FTL antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Purification: Protein G affinity chromatography

Immunogen: Amino acids 38-165 of human FTL were used as the immunogen for this Ferritin Light Chain antibody.

Clone: FTL-1386

Isotype: IgG2b

Application Details

Application Notes: Western blot: 0.1-0.2 μg/mL

Flow Cytometry: 0.1-0.2 μg/10^6 cells

IF: 0.1-0.2 μg/mL

IHC (FFPE): 0.1-0.2 μg/mL for 30 min at RT

The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the Ferritin Light Chain antibody to be titered up or down for optimal performance.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: PBS with 0.1 mg/mL BSA and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot and Store at -20C. Avoid freez-thaw cycles.

Target Details for FTL

Target: FTL (Ferritin, Light Polypeptide (FTL))

Alternative Name: FTL1 (FTL Products)

Synonyms: NBIA3 antibody, apoferritin antibody, ferritin antibody, fhc antibody, fth antibody, fth1 antibody, fthl6 antibody, ftn-2 antibody, pig15 antibody, plif antibody, FT antibody, Ftl antibody, Ftl-1 antibody, L-ferritin antibody, FTL antibody, Ftl1 antibody, FTL2 antibody, FTD antibody, ferritin light chain antibody, ferritin, heavy polypeptide 1 L homeolog antibody, ferritin light polypeptide 1 antibody, ferritin, light polypeptide antibody, ferritin light-chain antibody, ferritin light chain 1 antibody, FTL antibody, fth1.L antibody, Ftl1 antibody, CpipJ_CPIJ004069 antibody, Ftl antibody

Background: Mammalian ferritins consist of 24 subunits made up of 2 types of polypeptide chains, ferritin heavy chain and ferritin light chain. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe (III). Light chain ferritin is involved in cataracts by at least two mechanisms, hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of ageing-related cataracts.

Gene ID: 2512

UniProt: P02792

Pathways: Transition Metal Ion Homeostasis