p53 antibody

Catalog No. ABIN6253959

This Mouse Monoclonal antibody specifically detects p53 in FACS and ICC. It exhibits reactivity toward Mouse.

Quick Overview for p53 antibody (ABIN6253959)

Target: p53 (TP53) (Tumor Protein P53 (TP53))

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This p53 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: BP53-12

Product Details anti-p53 Antibody

Specificity: BP53-12, produces mouse IgG2a immunoglobulins recognizes both wild and mutant forms of 53 kD protein, identified as p53 suppressor gene

Purity: PURE

Isotype: IgG2a

Application Details

Application Notes: immunohistochemistry on paraffin tissue sections

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: 4 °C

Target Details for p53

Target: p53 (TP53) (Tumor Protein P53 (TP53))

Alternative Name: p53

Background: Antigen distribution: p53 is a tumor suppressor gene encoding a nuclear phosphoprotein that plays an important role in the control of normal cell proliferation. p53 is expressed in peripheral blood and bone marrow cells of patents with some hematological malignance. p53 protein quantitation is of value to ascertain malignancy and provides additional parameter suitable for evaluation of residual disease and for the monitoring of therapy and might also be one of the methods to indicate early relapse [1]. Cellular Expression: Human carcinoma.

Pathways: p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, Warburg Effect