E2F7 antibody
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- Target See all E2F7 Antibodies
- E2F7 (E2F Transcription Factor 7 (E2F7))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This E2F7 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Specificity
- E2F7 antibody detects endogenous levels of total E2F7
- Cross-Reactivity
- Human
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide
- Isotype
- IgG
- Top Product
- Discover our top product E2F7 Primary Antibody
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- Application Notes
- WB 1:500-1:2000 IHC 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- Target
- E2F7 (E2F Transcription Factor 7 (E2F7))
- Alternative Name
- E2F7 (E2F7 Products)
- Synonyms
- E2F7 antibody, E2F-7 antibody, fc43h03 antibody, si:dkey-217k21.2 antibody, wu:fc43h03 antibody, MGC154335 antibody, A630014C11Rik antibody, D10Ertd739e antibody, E2F transcription factor 7 antibody, E2F transcription factor 7 L homeolog antibody, E2F7 antibody, e2f7 antibody, e2f7.L antibody, E2f7 antibody
- Background
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Description: Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation.
Gene: E2F7
- Molecular Weight
- 99 kDa
- Gene ID
- 144455
- UniProt
- Q96AV8
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