BCOR antibody (Internal Region)

Catalog No. ABIN6257962

Product Details anti-BCOR Antibody

Target: BCOR (BCL6 Co-Repressor (BCOR))

Binding Specificity: Internal Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCOR antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: BCOR Antibody detects endogenous levels of total BCOR.

Predicted Reactivity: Pig,Bovine,Sheep,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human BCOR, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for BCOR

Target: BCOR (BCL6 Co-Repressor (BCOR))

Alternative Name: BCOR (BCOR Products)

Synonyms: ANOP2 antibody, MAA2 antibody, MCOPS2 antibody, BCOR antibody, RGD1562735 antibody, 5830466J11Rik antibody, 8430401K06Rik antibody, BcorR antibody, D930024N20Rik antibody, mKIAA1575 antibody, BCL6 corepressor antibody, BCL6 co-repressor antibody, BCL6 interacting corepressor antibody, BCOR antibody, bcor antibody, Bcor antibody

Background:

Description: Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A, impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells, the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).

Gene: BCOR

Molecular Weight: 192 kDa

Gene ID: 54880

UniProt: Q6W2J9