IFITM1 antibody (N-Term)

Catalog No. ABIN6259087

Product Details anti-IFITM1 Antibody

Target: IFITM1 (Interferon-Induced Transmembrane Protein 1 (IFITM1))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFITM1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: IFITM1 Antibody detects endogenous levels of total IFITM1.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human IFITM1, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Expiry Date: 12 months

Target Details for IFITM1

Target: IFITM1 (Interferon-Induced Transmembrane Protein 1 (IFITM1))

Alternative Name: IFITM1 (IFITM1 Products)

Synonyms: 9-27 antibody, CD225 antibody, DSPA2a antibody, IFI17 antibody, LEU13 antibody, 1110036C17Rik antibody, Mil-2 antibody, Mil2 antibody, interferon induced transmembrane protein 1 antibody, interferon induced transmembrane protein 1 (9-27) antibody, Ifitm1 antibody, IFITM1 antibody

Background:

Description: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation.

Gene: IFITM1

Molecular Weight: 14 kDa

Gene ID: 8519

UniProt: P13164